By Andrew K. Trull, Lawrence M. Demers, David W. Holt, Atholl Johnston, J. Michael Tredger, Christopher P. Price

ISBN-10: 0511064381

ISBN-13: 9780511064388

ISBN-10: 0521811023

ISBN-13: 9780521811026

This new ebook takes a severe, evidence-based examine the efficacy of recent diagnostic exams that are more and more getting used to judge organ harm and disorder. using biomarkers is growing to be, with a gentle move of latest items being introduced out through the pharmaceutical undefined. despite the fact that, in lots of situations the proof which helps using those new equipment in preference to conventional biochemical assessments has no longer but been validated, and it's meant that this quantity might help make clear the strengths and weaknesses of utilizing those biomarkers throughout quite a lot of functions and within the numerous organs of the physique. This method will offer a useful assessment of the varied purposes of biomarkers in medication.

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Extra info for Biomarkers of Disease: An Evidence-Based Approach

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Review of the HTA report: near patient testing in primary care. Bandolier, 45, 8. html) 4 King’s Fund (1998). Counting the Cost: The Real Impact of NonInsulin Dependent Diabetes, Kings Fund Policy Institute Report. 5 The Diabetes Control and Complications Trial Research Group (1993). The effect of intensive treatment of diabetes on the development and prognosis of long-term complications in insulin-dependent diabetes mellitus. New England Journal of Medicine 329, 977–86. 6 UKPDS Group (1998). Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).

12 R. A. 4. Frequency of use of methods of assessing test accuracy (50 physicians in each category) Bayesian method ROC curve Likelihood ratios Specialist physician Generalist physician Paediatrician General surgeon Family practice Obstetrics/gynaecology 5 2 1 0 0 0 1 0 1 1 0 0 1 1 0 0 0 0 Overall percentage 3% 1% 1% Source: From Read et al. [8]. Expressing results How do doctors use information about tests? A survey of US doctors [8] showed that almost none of them use these terms in any formal way.

Using numerical results from systematic reviews in clinical practice. Annals of Internal Medicine, 126, 712–20. L. J. (1998). Size is everything – large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects. Pain, 78, 209–16. W. and Heisterkamp, S. (1999). Empirical evidence of design-related bias in studies of diagnostic tests. JAMA, 282, 1061–6. S. R. (1995). Use of methodological standards in diagnostic test research: getting better but still not good.

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Biomarkers of Disease: An Evidence-Based Approach by Andrew K. Trull, Lawrence M. Demers, David W. Holt, Atholl Johnston, J. Michael Tredger, Christopher P. Price

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