By Panagiotis A. Tsonis
Now not uncomplicated line drawings on a web page, molecular constructions can now be seen in full-figured glory, usually in colour or even with interactive percentages. Anatomy of Gene legislation is the 1st booklet to offer the components and techniques of gene law on the 3-dimensional point. brilliant constructions of nucleic acids and their significant other proteins are printed in full-color, three-d shape. starting with a common creation to three-d buildings, the booklet seems on the association of the genome, the constitution of DNA, DNA replication and transcription, splicing, protein synthesis, and supreme protein dying. all through, the textual content employs a dialogue of genetics and structural mechanics. The concise and distinct synthesis of data will provide perception into gene legislation, and into the improvement of the right way to intrude with rules at diseased states. This textbook and its accompanying website are acceptable for either undergraduate and graduate scholars in genetics, molecular biology, structural biology, and biochemistry classes.
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Extra resources for Anatomy of Gene Regulation: A Three-dimensional Structural Analysis
A. Tainer, Cell 95: 135–46 (1998). Reprinted with permission from Elsevier Science. 17. A: 3-D structure of T7 DNA ligase. Domain 1 (N-terminal) is green and domain 2 (C-terminal) is red. ATP is shown in blue. D. B. Wigley, Cell 85: 607–15 (1996). B: Steps involved in the DNA ligation. First, the enzyme binds ATP with a lysine residue and forms an enzyme-AMP adduct (adenylation). Next, the adduct binds the 5 -phosphoryl group (transadelynation). Then, the adenyl group is displaced by the 3 -hydroxyl group, thus creating a phosphodiester linkage in the DNA strand.
The two metals are shown as red spheres. B: The nascent base pair (G-C; white) in the polymerase active site and the adjacent base pair of the primer-template (A-T; orange). Note the interactions between residues Arg-429 and Gln-615 with the minor groove of the A-T pair. T. Ellenberger, Nature 391: 251–8 (1998). Reprinted by permission from Nature, Macmillan Magazines Ltd. 35 36 Anatomy of Gene Regulation the incoming nucleotide ddGTP. ddGTP (cyan) stacks against the adenine at the 3 end of the primer (magenta) and forms a base pairing with a cytosine (yellow).
Its polymerase domain has the characteristic U shape with ﬁngers, palm, and thumb; however, there are some marked differences. The ﬁngers and thumb have different topologies than those seen in DNA polymerase I. The ﬁngers are made mainly of two antiparallel alpha helices; but the palm is topologically similar to the one in DNA polymerase I. The only difference is that gp43 has one of the three carboxylates (the amino acids that bind the incoming nucleotide) on a different beta strand. The overall structure of gp43 with the polymerase domain and the N-terminus domain, which contains the exonuclease domain, has a disk structure with a hole in the middle.
Anatomy of Gene Regulation: A Three-dimensional Structural Analysis by Panagiotis A. Tsonis
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