By Gordon Guyatt, Drummond Rennie, Maureen O. Meade, Deborah J. Cook
The best advisor to the rules and medical functions of evidence-based drugs.
Read Online or Download A Manual for Evidence-Based Clinical Practice (3rd Edition) (Users' Guides to the Medical Literature) PDF
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Extra resources for A Manual for Evidence-Based Clinical Practice (3rd Edition) (Users' Guides to the Medical Literature)
These patients undergo the new diagnostic test and a reference standard (also referred to as gold standard or criterion standard). Investigators evaluate the diagnostic test by comparing its classification of patients with that of the reference standard (Figure 4-6). A final type of study examines a patient’s prog nosis and may identify factors that modify that prognosis. Here, investigators identify patients who When randomized trials are not available, we look to observational studies in which—rather than randomization—clinician or patient preference, or happenstance, determines whether patients receive an intervention or alternative (see Chapter 6, Why Study Results Mislead: Bias and Random Error).
Practicing EBM requires clinicians to understand how uncertainty about clinical research evidence intersects with an individual patient’s predicament and preferences. In this chapter, we outline how EBM proposes to achieve these goals and, in so doing, define the nature of EBM. Three Fundamental Principles of EBM Conceptually, EBM involves 3 fundamental principles. First, optimal clinical decision making requires awareness of the best available evidence, which ideally will come from systematic summaries of that evidence.
If, as you use the medical literature, you find the need to expand your understanding of, for instance, studies address ing screening tests or the use of surrogate outcomes, you can consult the relevant chapters to familiarize or reacquaint yourself with the issues. You may also find the glossary a useful reminder of the formal defini tions of terms used herein. Finally, we rely heavily on BOX 1-1 Sections of This Book The Foundations Therapy Harm Diagnosis Prognosis Summarizing the Evidence Moving From Evidence to Action aThe italicization, here and in every other chapter, represents the first occurrence in the chapter of a word defined in the glossary.
A Manual for Evidence-Based Clinical Practice (3rd Edition) (Users' Guides to the Medical Literature) by Gordon Guyatt, Drummond Rennie, Maureen O. Meade, Deborah J. Cook
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